Imatinib Mesylate 100mg

What is Imatinib Mesylate?

Imatinib Mesylate is a breakthrough tyrosine kinase inhibitor (TKI) medication primarily used to treat:
✔ Chronic Myeloid Leukemia (CML)
✔ Gastrointestinal Stromal Tumors (GIST)
✔ Philadelphia Chromosome-Positive ALL (Ph+ ALL)
✔ Dermatofibrosarcoma Protuberans (DFSP)

As the generic version of Gleevec, these tablets offer targeted cancer therapy by blocking abnormal proteins that cause uncontrolled cell growth.

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How Imatinib Mesylate Works

This targeted therapy drug works through a unique mechanism:

1. BCR-ABL Inhibition – Blocks the abnormal Philadelphia chromosome protein in CML
2. KIT Protein Suppression – Targets GIST tumor growth factors
3. PDGFR Inhibition – Stops DFSP cancer cell proliferation

Key Benefits:

• Higher specificity than chemotherapy
• Fewer side effects than traditional treatments
• Proven efficacy in clinical trials

Complete Imatinib Mesylate Dosage Guide

Standard Dosages:

Administration Tips:

• Take with food to reduce nausea
• Swallow whole with large glass of water
• Dose adjustments may be needed for liver/kidney impairment

Note: Always follow your oncologist’s prescribed dosage.

Imatinib Mesylate Side Effects & Safety

Common Side Effects (Manageable):

• Mild nausea & diarrhea
• Muscle cramps
• Fatigue
• Skin rashes

Serious Side Effects (Require Medical Attention):

• Severe fluid retention
• Liver toxicity
• Low blood counts
• Heart problems

Safety Precautions:
✔ Regular blood tests required
✔ Avoid grapefruit juice
✔ Not recommended during pregnancy

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Imatinib Mesylate vs Other TKIs

Why Imatinib Remains First-Line Treatment?

• Longest safety record
• Most affordable TKI
• Proven long-term results

Frequently Asked Questions

1. Is generic Imatinib as effective as Gleevec?

Yes, FDA-approved generics contain the exact same active ingredient at identical strengths.

2. How long until Imatinib shows results?

Most CML patients see improved blood counts within 3 months, with major molecular response typically in 12-18 months.

3. Can I stop taking Imatinib if I feel better?

Never stop without oncologist approval – discontinuation risks relapse in most cases.

4. What foods should I avoid?

Avoid grapefruit and limit St. John’s Wort as they affect drug metabolism.

5. How should I store Imatinib tablets?

Keep at room temperature (15-30°C) in original packaging.

Why Imatinib Mesylate Remains the Gold Standard

After 20+ years of use, Imatinib continues to be the most prescribed TKI because:

1. Proven survival benefits (85% 10-year survival for CML)
2. Manageable side effect profile
3. Cost-effective compared to newer TKIs
4. Extensive real-world experience

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